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RBPJ Inhibitor-1

CAS No. 2682114-39-0

RBPJ Inhibitor-1( —— )

Catalog No. M34771 CAS No. 2682114-39-0

RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RBPJ Inhibitor-1
  • Note
    Research use only, not for human use.
  • Brief Description
    RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation.
  • Description
    RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation.
  • In Vitro
    Cell Viability Assay Cell Line:AD-293 cells were transfected with RBPJ-VP16myc.Concentration:2 μM.Incubation Time:17 hours.Result:Inhibited Hes1-Luciferase activity with an IC50 of 0.18 μM and Emax of 82%.Inhibited NOTCH3 ICD with similar potency and efcacy (0.19 μM and Emax=88%).Cell Proliferation Assay Cell Line:T-cell acute lymphoblastic leukemia (T-ALL) patients (Jurkat and KOPT-K1) and in the mantle cell lymphoma (MCL) line REC-1.Concentration:0.1-10 μM.Incubation Time:96 h. Result:Inhibited NOTCH-dependent tumor cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    Gamma-secretase
  • Recptor
    Gamma-secretase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2682114-39-0
  • Formula Weight
    311.31
  • Molecular Formula
    C17H14FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (803.06 mM; Ultrasonic )
  • SMILES
    O(C1=C(C(N)=O)C=CC(=C1)C=2N(C)N=CC2)C3=C(F)C=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.?
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